The Cuvelai catchment falls between the Kunene catchment in the west and Cubango/Okavango catchment in the east; and it empties into Etosha pan through the Ekuma River. The system supports a variety of animals and plants. Since the system is tempprary it only holds water during the wet season, it support large numbers of short-lived animals such as macroinvertebrates. These organisms can be used to assess the health of the wetlands in a process referred to as biological monitoring. The main aim of this study was to develop a monitoring framework for the wetlands in the Cuvelai, and also to compare with the study done on the system about ten years ago. To achieve these aims, a biological sampling method, using, scoop nets to collect macroinvertebrates from different habitats from oshanas or watercourses and ondombes or deep pools was established. The invertebrates found were used to draw conclusions about the health integrity of the wetlands; using the relative abundances of Taxa sensitive to water quality (e.9. Tabanidae) and tolerant taxa (e.9. Chironomidae). Branchipodopsis spp, Daphnia spp, Lovenula falcifera and notonectids recorded the highest abundance and were compared to what was found in 1997. No major changes were detected and it could be concluded that the water quality is still in a good condition. From the vegetation collected, there were not many changes; however, sites like Ogongo east and Lashivanda recorded large populations of Pechuel-Loeschea leubninitziae and Geigeria ornativa which are associated with and indicative of overgrazing. It was recommended that for the protection and sustainable management of our wetlands, the Department of Water Affairs together with other involved ministries such as MET and MFMR and also traditional authorities should work together