The Okavango River is one of the largest and most important rivers in Southern Africa. The river rises in Angola, a country that has just emerged from a civil war of three decades. The annual flood pulse of the river feeds the Okavango Delta: one of the most valuable environmental resources of the African continent. The Okavango River water and its ecosystem resources are critically important sources of livelihoods in the basin. Pressures from livelihoods and development are already impacting on the environment and are likely to increase. Moreover, future development will occur against the background of climate variability and change. This chapter describes research conducted under the EU-funded project'Water and Ecosystem Resources in Regional Development' (WERRD), whose aims included development of scenario modelling as a tool for integrated water resource management in the Okavango River basin. Keywords: climate change, impacts, hydrology, hydrological model, water resources, adaptation, uncertainty, Okavango, scenarios.