We provide a position paper, using a brief literature review and some new modelling results for a subset of succulent plant species, which explores why Namaqualand plant diversity might be particularly vulnerable to anthropogenic climate change despite presumed species resilience under arid conditions, and therefore a globally important test-bed for adaptive conservation strategies. The Pleistocene climate-related evolutionary history of this region in particular may predispose Namaqualand (and Succulent Karoo) plant endemics to projected climate change impacts. Key Succulent Karoo plant lineages originated during cool Pleistocene times, and projected air temperatures under anthropogenic climate change are likely to exceed these significantly. Projected rainfall patterns are less certain, and projections of the future prevalence of coastal fog are lacking, but if either of these water inputs is reduced in concert with rising temperatures, this seems certain to threaten the persistence of, at least, narrow-endemic plant species. Simple modelling approaches show strong reduction in spatial extent of bioclimates typical of Namaqualand within the next five decades and that both generalist species with large geographic ranges, and narrow-range endemics may be susceptible to climate change induced loss of potential range. Persistence of endemics in micro-habitats that are buffered from extreme climate conditions cannot be discounted, though no attempts have been made to address this shortcoming of broader scale bioclimatic modelling. The few experimental data available on elevated temperature and drought tolerance suggest susceptibility of leaf succulent species, but high drought tolerance of non-succulent shrubs. Both species-level monitoring and further experimental work is essential to test and refine projections of climate change impacts on species persistence, and the implications for conservation. Keywords: Drought, Tolerance limits, Bioclimatic modelling, Desert, Range shifts.