To complement the Southern Namibian Mapping Programme (Nguno and Macey, 2024), an investigation of the mineral potential of the south eastern //Karas Region was conducted simultaneously with the field work as an incentive for further exploration. Until the year 2000, the former Sperrgebiet (now Tsau//Khaeb National Park) was reserved solely for exploration and mining of precious stones (alluvial diamonds) along the Atlantic seaboard and Orange River, rendering the huge area between Oranjemund and Lüderitz underexplored with respect to other commodities. That such potential exists is indicated by major mining operations just outside its borders, i. e. the Skorpion Zn and the Rosh Pinah Zn Pb Ag Mines, which are part of a major base metal province. The Gergarub Zn Pb Ag deposit, situated some 15 km northwest of Rosh Pinah on farm Spitskop 111, constitutes such an unexploited resource, within this province. Other past and present mining operations in the project area (Figs 1 and 2) include the Aukam Graphite, Tin and Fluorite Mines, as well as several dimension stone quarries. Keywords: Mineral exploration, Mineral potential, Sperrgebiet.