Kabwe is a city in the Republic of Zambia that is heavily polluted with heavy metals, specifically with lead (Pb) and cadmium (Cd). For over 25 years since the closure of the mining area in 1994, Kabwe residents remain to feel the environmental, social, and biological effects of lead contamination. Several studies have been conducted - flora, fauna, soil, and blood - yet there is a lack of a systematic review summarizing such studies. This study conducted a systematic review of published quantitative research in Kabwe and investigates interventions conducted by different entities. The aim of this paper is to describe recommendations for future interventions conducted in Kabwe using a One Health approach informed by relevant Zambian development objectives. Keywords: Kabwe, lead, environment, heavy metals, One Health, 7ND.