Arid regions are characterized by high unpredictability of rainfall. Consequently, ecosystems along their margins are naturally oscillating but usually resilient. Here, we report the severe and potentially irreversible degradation of vegetation, ecosystems, and biodiversity in the northernmost more than 1 million ha of the Succulent Karoo, a global biodiversity hotspot. In our study, we use monitoring data spanning 45 years to disentangle different processes of change which started decades ago. The regionally important, vulnerable ecosystem "Gariep silty plains" is inhabited by the species-rich vegetation alliance Brownanthion pseudoschlichtiani. The cushion-like dwarf shrub scorpionstail (Brownanthus pseudoschlichtianus, Aizoaceae) is the dominant plant species protecting the soil and facilitating silt sedimentation. Following disturbances, this vegetation type is thinning and losing perennial plant species. This allows aeolian erosion, which - as a tipping point - turns the silty topsoil into sandy soil across extensive areas. Increased mobilisation of aeolian sand causes abrasion and sedimentation, which buries vast landscapes. The newly developed sandy topsoils are invaded by species-poor grassland communities partly typical for the Namib Desert biome. We present a novel S and T model and discuss cascading effects which threaten nature, farmland and infrastructure. Farming, mining, road construction and climate change may be interacting drivers of degradation. Keywords: Biodiversity monitoring, Tipping points, Aeolian transport, dust, sand, Richtersveld.