This chapter is a modest attempt to showcase local knowledge of plant remedies used for managing HIV-related diseases and symptoms in Namibia. To help put it in perspective, the chapter first describes the HIV/AIDS scenario in Namibia, which includes the indigenous names and terms related to HIV infection and AIDS, and describes the challenges facing antiretroviral therapy (ART). It then goes onrnto examine the prospects for using ethnomedicines in Namibia and the processes for initiating collaboration with traditional healers. Finally, the chapter focuses on ethnobotanical surveys of plants used to treat the symptoms and opportunistic infections related to HIV/AIDS in Zambezi (formerly Caprivi) and Ohangwena regions of Namibia. This chapter is an extension of the rich vein of publications based on previous fieldwork in north-eastern Namibia.