The use of chemical pesticides and pharmaceutical drugs to manage livestock pests and diseases is anathema to the environment and leads to the development of resistance. Most resource-poor farmers also face problems, such as inaccessibility, unaffordability and inappropriate use of chemical pesticides and drugs. Faced with these constraints, livestock farmers in Namibia and other African countries turn to indigenous knowledge as an alternative option and as a key to unlock the power of plants to control various vectors and diseases of livestock.