Using a meta-analytical research design, we analyzed subnational case studies (n = 132) on the causes of dryland degradation, also referred to as desertification, to determine whether the proximate causes and underlying driving forces fall into any pattern and to identify mediating factors, feedback mechanisms, cross-scalar dynamics, and typical pathways of dryland ecosystem change. Our results show that desertification is driven by a limited suite of recurrent core variables, of which the most prominent at the underlying level are climatic factors, economic factors, institutions, national policies, population growth, and remote influences. At the proximate level, these factors drive cropland expansion, overgrazing, and infrastructure extension. Keywords: desertification, dryland degradation, feedbacks, pathways, causes.