The study of the medicinal and aromatic plants used by the Topnaar is part of the ethnobotanical survey of the Namib desert, carried out by the authors. To obtain data, Topnaar people living in the Namib desert were visited. A list of interesting plants species is produced (including plant name, systematic classification and ethnobotanical properties). Several plants were analysed for active substances. The results are presented and discussed. Subjects: medicinal plants, essential oils, ethnobotany, medicinal properties, traditional medicine, Namibia.