A systematic account of specimens of reptiles and amphibians collected in the course of an expedition to South-West Africa and Little Namaqualand. A total of 1416 specimens, representing 104 species and subspecies, was collected. One tortoise and 8 lizards are described as new. The itinerary and situation of all localities at which specimens were collected are marked on an accompanying map. Keywords: Amphibian, Little Namaqualand, Reptile, South-West Africa and Systematic account.