This Wildlife Crime Scene Protocol Manual serves as a resource for national and local level law enforcement engaging with wildlife crime scenes. This manual provides the standard operating procedures for officers responding to wildlife crime scenes with a special focus on poison mitigation and handling. This manual is intended for use in conjunction with official poison crime scene training provided by mitigation agencies. The manual covers crime-scene management, evidence collection, victim management, chain of custody maintenance, personal protection and decontamination procedures required for successful prosecution following a wildlife crime. This manual was created by NARREC - Namibia Animal Rehabilitation and Research Center and humaneLABS wildlife praxis.