In the southern portion of the Damara Orogen of Namibia large bodies of megacrystalline quartz and dolomite, many of them with a core of silicified dolomitic breccia that generally exhibits intrusive patterns, are abundant. Systematic fluid inclusion studies on the quartz-dolomite bodies by means of decrepitometry and microthermometry revealed that three phases of fluid activity led to the formation and alteration of the quartz-dolomite bodies. Most of the quartz and dolomite formed from a highly saline fluid phase which was generated by dehydration and leaching of the evaporitic Duruchaus Formation. The general characteristics of these genetic fluids are high salinity (38 vol% NaCI) and high oxygen fugacity (minimum log fO2 -30). Minimum temperatures of formation ranged from 130°C to possibly as high as 330°C. A second fluid phase with a distinctly higher CO2 content, but still high salinity, developed and formed a quartz stockwork in the surrounding wall rock. Total homogenization temperatures for the inclusions are 180° to 230°C. In the quartz-dolomite bodies this fluid phase formed secondary and pseudosecondary inclusions. In the quartz stockwork this phase is characterized by very variable gas-liquid ratios and high CO2 content of the fluid inclusions which is interpreted as the result of boiling. A third fluid phase that led to strong alteration of the quartz-dolomite bodies consisted of almost pure CO2 . A minimum pressure of formation of 3 kbar was determined from these inclusions. Mineral parageneses were used to estimate pH-fO2 conditions. The various fluid phases can be related to different stages of the tectonic development of the Damara Orogen.