This paper compares the structural development and the lithofacies evolution of the manganese-bearing sedimentary sequence at Otjosondu in the east with that of the Damara Sequence as it is developed laterally along the tectonic strike of the exposed southern Central Zone of the Damara inland branch. Structural patterns of three deformational events can be correlated. D1 folds are recognised throughout the Central Zone; the D2 phase is the dominant deformation event in all areas, whereas D3 patterns increase in their intensity towards the southwest. The facies distribution reflects two major Late Proterozoic transgressions. The first one (base of the Swakop Group) marks the opening of the Adamastor Ocean, in which sequences were deposited on an uneven topography. The second one at the base of the Chuos Formation was associated with the opening of the Khomas Sea which led to a major transgression throughout the area under consideration, and to the development of pelagic shelf Mn and Fe deposits at Otjosondu. The facies differentiation within the Chuos Formation reveals different depositional controls laterally along the shelf platform of the southern Central Zone. The detailed study of deformation patterns and lithostratigraphy confirms the validity of previous broad correlations of the lithologies at Otjosondu with those of the Damara Sequence as a whole.