Addressing climate change and transforming agri-food systems are key to meeting the Sustainable Development Goals (SDGs). With nearly 690 million people around the world facing hunger today (FAO et al., 2020), agri-food systems emitting one third of global anthropogenic GHG emissions (Crippa et al., 2021) and a growing public demand for climate action, it is pressing to achieve food security while adapting to - and mitigating - climate change. Climate-smart agriculture (CSA) has grown from a concept into an approach implemented throughout the world, by all types of stakeholders. This publication describes climate-smart agriculture case studies that apply the five action points for CSA implementation. The action points are: 1) expanding the evidence base for CSA, 2) supporting enabling policy frameworks, 3) strengthening national and local institutions, 4) enhancing funding and financing options, and 5) implementing CSA practices at field level. The five action points were created by the Food and Agriculture Organization of the United Nations (FAO) as a methodology for implementing the climate-smart-agriculture approach at a national scale. These action points provide the structure for this publication. The case studies discuss context-specific activities that contribute to CSA’s three pillars: sustainably increasing agricultural productivity and incomes, adapting and building resilience of people and agri-food systems to climate change, and reducing and/or removing greenhouse gas emissions where possible. Many of the case studies pay special attention to smallholder farmers, including women and indigenous groups, who are particularly affected by the impacts of climate change. A diverse group of stakeholders contributed case studies, reflecting the importance of coordinating national-level CSA activities, for example by including research findings in policymaking processes, and leveraging public sector funding to attract private sector investment. The publication provides examples of the innovative roles that farmers, researchers, government officials, private sector and civil society actors can play to transform agri-food systems and help meet the SDGs; it also demonstrates how these actors can collaborate.