Tanzania is home to wild herds of buffalo, wildebeest, hartebeest, and impala that have been hunted for meat by generations of indigenous communities. In 2019, Tanzania’s late President called on the country’s authorities to establish a mechanism that will allow Tanzania's to access wild meat, counter rampant poaching and illegal bushmeat trade through a pioneering set of national laws. By early 2020, the Game Meat Selling Regulations (GMSR) - new legislation for the legal sourcing, selling, and consumption of wild meat - had come into force. In the short time since, the legislative landscape of domestic wild meat trade has radically changed, even if effective implementation and public awareness are yet to catch up. TRAFFIC’s report From Bush to Butchery analyses the impact, gaps and opportunities of Tanzania’s new regulations from conservation, traceability, community, and economic perspectives. TRAFFIC used a multi-sectoral One Health approach to engage wildlife, livestock, and public health officials from district level up to national agencies as the project's foundation for developing practical recommendations. Given its potential for application in other African countries facing similar issues, TRAFFIC's report adds to ongoing collaboration with local authorities with a set of evidence-based insights to help guide future improvements in Tanzania and beyond. While the GMSR are ambitious in scope, they hold the potential to trailblaze similar approaches that could be adopted elsewhere - law enforcement, monitoring of hunting and trade, safety inspections, and public awareness need to be stepped up.