Epigenetic, rare earth element, gold, tin and tungsten, mineralisation in the northeast-trending, intracratonic branch of the deeply eroded, late Proterozoic/early Palaeozoic, Pan-African Damara Orogen is hosted by meta-arkoses, marbles and metaturbidites in the magmatic arc (Central Zone; CZ) of the orogen, a tectono-stratigraphic entity characterised by multiple deformation, green-schist/amphibolite- acies, low-pressure/high-temperature metamorphism and numerous granitic and pegmatitic intrusions. This memoir integrates regional and detailed geological mapping with petrographic studies, whole-rock geochemistry (obtained by X-ray fluorescence spectrometry, atomic absorption spectrometry, fire assay and infrared spectroscopy), mineral chemistry studies (electron microprobe and X-ray diffraction) and geochronological work (Rb-Sr whole-rock and mineral age determinations and Pb-Pb model ages) to examine six examples of metasediment-hosted epigenetic mineralisation in the Usakos-Karibib-Omaruru district, central Namibia. The investigated area straddles the magnetically defined Omaruru Lineament, which divides the CZ into southern (SCZ) and northern (NCZ) portions. Geological mapping and lithostratigraphic work support the geophysical evidence for this subdivision: in the SCZ, predominantly continental and shallow marine Damaran metasediments are floored by a 1.7-2.0 Ga granite gneiss basement inlier, that is transected by numerous east-northeast-trending auriferous megashears.