Acanthosicyos naudininus, Gomphocarpus fruticosus, and Cryptolepis decidua are, according to the knowledge of traditional healers, used in Namibia to treat inflammatory disorders such as pain, fever and skin rashes. Aim of the study: The present study was conducted to evaluate the immunomodulatory effects and the possible underlying mechanisms of action of the plant extracts on peripheral blood mononuclear cells (PBMCs) such as T-lymphocytes. Keywords: Immunomodulatory, Lymphocytes, Inflammation, Traditional medicine, Namibia, Acanthosicyos naudinianus, Gomphocarpus fruticosus, Cryptolepis decidua.