The widespread ethnic usage of Boophone disticha has justified its standing as a flagship for the Amaryllidaceae and its relevance to South African traditional medicine. Furthermore, its promising pharmacological and phytochemical profiles have stimulated significant interest in the clinical realm, especially in the areas of cancer and motor neuron disease chemotherapy. These collective properties should prove useful in steering the progress of the plant towards a wider audience. Keywords: AChE, AD, Alkaloid, Alzheimer's disease, Amaryllidaceae, BW, Boophone disticha, CNS, COX, IK, LD, MAO, MBC, MIC, MND, MTD, OFS, Orange Free State, PD, Parkinson's disease, SSRI, T/C index, TM, Traditional medicine, acetylcholineserase, body weight, central nervous system, cyclo-oxygenase, indigenous knowledge, lethal dose, minimum bactericidal concentration, minimum inhibitory concentration, minimum toxic dose, monoamine oxidase, motor neuron disease, ratio of treated and control group, selective serotonin reuptake inhibitor, traditional medicine.