The physicochemical characteristics, fatty acid, tocopherol, stigmasterol, b-sitosterol, and 1 H NMR profiles of Citrullus lanatus and Acanthosicyos horridus melon seed oils were determined and compared among different extraction methods (cold pressing, traditional, and Soxhlet). The oil content was 40.2 ± 3.45 and 37.8 ± 7.26% for C. lanatus and A. horridus, respectively. Significant differences (p<0.05) were observed among the different extraction methods in the characteristics studied. Physicochemical characteristics of the melon seed oils were saponification value, 180.48–189.86 mg KOH/g oil; iodine value, 108.27–118.62 g I2/100 g oil; acid value, 0.643–1.63 mg KOH/g oil; peroxide value; 1.69–2.98 mequiv/kg oil; specific gravity, 0.901–0.922; and refractive indices, 1.4676–1.4726. The dominant tocopherol was c-tocopherol with total tocopherol in the range 27.61–74.39 mg/100 g. The dominant fatty acid was linoleic acid in the range 52.57–56.96%. The favorable oil yield, physicochemical characteristics, tocopherol, and fatty acid composition have the potential to replace or improve major commercial vegetable oils and to be used for various applications in the food industry and nutritive medicines. Keywords: Namibia, Melon seed oils, Acanthosicyos horridus, Citrullus lanatus, Physicochemical characterization.