An interdisciplinary study (major and minor elements, C and O isotopes, heavy and light minerals, phyllosilicates, wireline logs) in northern Namibia unraveled the hydrographic and hydraulic evolution of alluvial-fluvial sediments of the Kunene and Cubango megafans (Etosha-Cuvelai Basin). Three principal aquatic regimes were operative within the megafan complex: (1) the hydrographic regime, (2) the proximal hydraulic regime, (3) the distal hydraulic regime. The allogenic mineral assemblages mirror the hydrographic variation or drainage system and the lithological evolution of the fan sediments (alluvial-fluvial fan, lacustrine environment with evaporites, fan delta progradation). Authigenic heavy minerals are markers of the physical-chemical condition (Eh and pH values) of the hydraulic regime within the proximal fan at the basin margin. Authigenic heavy, light and clay minerals equally contribute to the determination of the fluid chemistry and temperature, as well as the source of chemical constituents of the former pore fluids percolating through the distal fan. Carbonatization was the most pronounced event in the distal hydraulic system and controlled by the presence of biogenic as well as atmospheric carbon. The isotope-based determination of the temperatures, albeit strongly fluctuating, do not exceed 40 °C. The overall pH values determined for the hydraulic regime within the distal fan range from slightly acidic to alkaline. The presence of zeolites attests to some short-lasting but strong deviations from the pH range, mainly towards more alkaline conditions. Heavy, light and clay mineral analyses proved to be a useful tool to determine the (paleo)hydrology of alluvial-fluvial fan systems in tropical arid to semiarid climates.Keywords: Heavy and light minerals, Hydrographic regime, Hydraulic regime, Inland fan deposits, Cuvelai-Etosha Basin, North Namibia.