Harpagophytum procumbens subps. procumbens (Burch.) DC. ex Meisn. (Pedaliaceae) is an important traditional medicine growing in the Kalahari region of southern Africa where it is consumed as a general health tonic and for treating diverse ailments including arthritis, pain, fever, ulcers and boils. Keywords: Biological activity, Devil's Claw, Ethnobotany, Harpagophytum procumbens, Harpagoside, Iridoids, Phenylpropanoid glycosides, Phytochemistry.