The Rehoboth Province of southern Africa is defined by its smooth magnetic character by contrast to the adjoining mobile belts. It has been slow to yield information about its crustal evolution because most of it is covered by Kalahari sands. A combined microbeam study of U-Pb, Lu-Hf in zircon from metasedimentary and magmatic rocks of the well-exposed Rehoboth Basement Inlier (RBI) provides new constraints on the crustal evolution of the Rehoboth Province. The detrital zircons provide evidence for five U-Pb age groups corresponding to magmatic events within the crust, whereas Lu-Hf zircon data allows estimates of crustal residence age. Zircon oxygen isotope data for the magmatic rocks implies diversity in their genesis. Keywords: Rehoboth Province, Rehoboth Basement Inlier, U-Pb geochronology, Hf and oxygen isotopes, Detrital zircon, Crustal evolution.