The genus Pegolettia (Compositae, Inuleae) from Africa, Arabia, and the Middle East is revised. The nine recognized species, viz. P. lanceolata Harv., P. baccaridifolia Less., P. gariepina A. Anderb., P. oxyodonta DC., P. retrofracta (Thunb.) Kies, P. tenuifolia Bolus, P. plumosa M. D. Hend., P. pinnatilobata (Klatt) O. Hoffm. ex Dinter, and P. senegalensis Cass., are treated cladistically, and a cladogram is presented. The species are illustrated, and their distributions mapped. Hypotheses on the mode of speciation and the biogeography of the group including a model of area relationships in southern Africa are presented.